OPTO-19F-LUIDICS: FLUORINATED HYBRID PHOTOPOLYMERS FOR THE FABRICATION OF ROBUST DIAGNOSTIC OPTOFLUIDIC DEVICES
OPTO-19F-LUIDICS
Funded by: MUR
Calls: PRIN 2022
Start date: 2023-09-28 End date: 2025-09-27
Total Budget: EUR 231.254,00 INO share of the total budget: EUR 84.050,00
Scientific manager: and for INO is: Credi Caterina
Organization/Institution/Company main assignee: CNR – Istituto Nazionale di Ottica (INO)
Calls: PRIN 2022
Start date: 2023-09-28 End date: 2025-09-27
Total Budget: EUR 231.254,00 INO share of the total budget: EUR 84.050,00
Scientific manager: and for INO is: Credi Caterina
Organization/Institution/Company main assignee: CNR – Istituto Nazionale di Ottica (INO)
other Organization/Institution/Company involved:
Politecnico di Milano
Università degli Studi di Firenze
other INO’s people involved: Calamai Martino
Abstract: The OPTO-19F-LUIDICS project aims at developing new materials for the fabrication of optofluidic devices for the detection of Alzheimer’s Disease AD pathological biomarkers in cerebrospinal fluid through surface enhanced Raman spectroscopy (SERS). Indeed, by selectively monitoring the changes in the molecular composition of biofluids, it is possible to discriminate between physiological and pathological conditions.
First actions focus on the synthesis of perfluoropolyether polymers PFPEs by photopolymerization. Then, best-performing PFPE are exploited to fabricate devices by combining traditional and advanced manufacturing techniques enabling for low-cost rapid prototyping.
The second task is focused on the engineering of Au nanoparticles (NPs) working as SERS substrates. Functionalization strategies will be implemented i) to increase the NPS affinity towards the AD hallmarks and thus, to selectively amplify their Raman signal with respect to the overall liquid matrices; ii) to anchor Raman labels characterized by peaks in the biologically silent Raman region and enabling to decrease the back-ground spurious signal.
Finally, the challenging output of the project is to smartly combine microfluidics and SERS with improved materials properly conceived for AD early-stage diagnosis but representing to be a universal platform for SERS molecular sensing and diagnostics.
First actions focus on the synthesis of perfluoropolyether polymers PFPEs by photopolymerization. Then, best-performing PFPE are exploited to fabricate devices by combining traditional and advanced manufacturing techniques enabling for low-cost rapid prototyping.
The second task is focused on the engineering of Au nanoparticles (NPs) working as SERS substrates. Functionalization strategies will be implemented i) to increase the NPS affinity towards the AD hallmarks and thus, to selectively amplify their Raman signal with respect to the overall liquid matrices; ii) to anchor Raman labels characterized by peaks in the biologically silent Raman region and enabling to decrease the back-ground spurious signal.
Finally, the challenging output of the project is to smartly combine microfluidics and SERS with improved materials properly conceived for AD early-stage diagnosis but representing to be a universal platform for SERS molecular sensing and diagnostics.