Plastic Lab-on-cips for the optical manipulation of Single-cells
PLUS
Funded by: Ministero dell’Istruzione, Università e Ricerca (MIUR)
Calls: Progetto Bandiera – La Fabbrica del Futuro
Start date: 2013-01-15 End date: 2014-01-14
Total Budget: EUR 186.000,00 INO share of the total budget: EUR 98.600,00
Scientific manager: Osellame Roberto and for INO is: Ferraro Pietro
Organization/Institution/Company main assignee: CNR – Istituto di Fotonica e Nanotecnologie (IFN)
Calls: Progetto Bandiera – La Fabbrica del Futuro
Start date: 2013-01-15 End date: 2014-01-14
Total Budget: EUR 186.000,00 INO share of the total budget: EUR 98.600,00
Scientific manager: Osellame Roberto and for INO is: Ferraro Pietro
Organization/Institution/Company main assignee: CNR – Istituto di Fotonica e Nanotecnologie (IFN)
other Organization/Institution/Company involved:
JULIGHT s.r.l.
KIRANA s.r.l.
NOVAETECH s.r.l.
OPTSENSOR s.r.l.
SELEX – Sistemi Integrati S.p.A.
other INO’s people involved: Paturzo MelaniaBattista Luigi
Abstract: Lab-on-chips (LoCs) are microsystems capable of manipulating small amounts of fluids in microfluidic channels. They have a huge application potential, from basic science to chemical synthesis and point-of-care medical analysis. Polymers are rapidly emerging as the material of choice for LoC production, due to the low substrate cost and ease of processing. Two breakthroughs that could promote LoC diffusion are: (i) a microfabrication technology with low-cost rapid prototyping capabilities; (ii) an integrated on-chip optical detection system.
In this project we propose the use of femtosecond lasers and microinjection moulding as a novel highly-flexible microfabrication platform for polymeric LOCs with integrated optical detection, for the realization of low-cost and truly portable biophotonic microsystems. In this project we target the relevant application of LoCs to non-invasive contactless mechanical phenotyping of single cancer cells.
In this project we propose the use of femtosecond lasers and microinjection moulding as a novel highly-flexible microfabrication platform for polymeric LOCs with integrated optical detection, for the realization of low-cost and truly portable biophotonic microsystems. In this project we target the relevant application of LoCs to non-invasive contactless mechanical phenotyping of single cancer cells.