A device for continuous monitoring of true central fixation based on foveal birefringence

Year: 2013

Authors: Gramatikov B., Irsch K., Müllenbroich M., Frindt N., Qu Y., Gutmark R., Wu Y.-K., Guyton D.

Autors Affiliation: Division of Pediatric Ophthalmology and Adult Strabismus, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Wilmer 233, 600 N. Wolfe St, Baltimore, MD 21287, United States

Abstract: A device for continuous monitoring of central fixation utilizes birefringence, the property of the Henle fibers surrounding the human fovea, to change the polarization state of light. A circular scan of retinal birefringence, where the scanning circle encompasses the fovea, allows identification of true central fixation – an assessment much needed in various applications in ophthalmology, psychology, and psychiatry. The device allows continuous monitoring for central fixation over an extended period of time in the presence of fixation targets and distracting stimuli, which may be helpful in detecting attention deficit hyperactivity disorder, autism spectrum disorders, and other disorders characterized by changes in the subject\’s ability to maintain fixation. A proof-of-concept has been obtained in a small study of ADHD patients and normal control subjects.


Volume: 41 (9)      Pages from: 1968  to: 1978

More Information: – This research supported in part by gifts from grateful patients, with major contributions from Diane and Robert Levy of Chicago. The authors thank the Division of Pediatric Ophthalmology at the Wilmer Eye Institute and especially Hee-Jung Park, M.D. and Alex Christoff, C.O., C.O.T, for providing the test subjects.
KeyWords: ADHD; ASD; Attention; Autism; Eye fixations; Vigilance, Diseases; Fatigue of materials; Monitoring; Ophthalmology; Stresses, Birefringence, article; attention deficit disorder; birefringence; child; computer interface; controlled study; diode laser; discriminant analysis; eye fixation; eye fundus; female; human; laser safety; male; normal human; ophthalmic fixation device; pilot study; polarization; retina fovea; school child; signal processing, Attention Deficit Disorder with Hyperactivity; Birefringence; Child Development Disorders, Pervasive; Fixation, Ocular; Fovea Centralis; Humans; Male; Monitoring, Physiologic
DOI: 10.1007/s10439-013-0818-2

Citations: 10
data from “WEB OF SCIENCE” (of Thomson Reuters) are update at: 2022-06-26
References taken from IsiWeb of Knowledge: (subscribers only)
Connecting to view paper tab on IsiWeb: Click here
Connecting to view citations from IsiWeb: Click here