Bioconjugated silicon quantum dots from one-step green synthesis

Year: 2012

Authors: Intartaglia R., Barchanski A., Bagga K., Genovese A., Das G., Wagener P., Di Fabrizio E., Diaspro A., Brandi F., Barcikowski S.

Autors Affiliation: Department of Nanophysics, Istituto Italiano di Tecnologia, via Morego, 30, 16163, Genova, Italy;
Laser Zentrum Hannover E.V., Nanotechnology Department, Hollerithallee 8, 30419, Hannover, Germany;
Department of Nanochemistry, Istituto Italiano di Tecnologia, via Morego, 30, 16163, Genova, Italy;
Technical Chemistry i, Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstrasse 7, 45141, Essen, Germany;
Department of Nanostructure, Istituto Italiano di Tecnologia, via Morego, 30, 16163, Genova, Italy

Abstract: Biofunctionalized silicon quantum dots were prepared through a one step strategy avoiding the use of chemical precursors. UV-Vis spectroscopy, Raman spectroscopy and HAADF-STEM prove oligonucleotide conjugation to the surface of silicon nanoparticle with an average size of 4 nm. The nanoparticle size results from the size-quenching effect during in situ conjugation. Photoemissive properties, conjugation efficiency and stability of these pure colloids were studied and demonstrate the bio-application potential, e.g. for nucleic acid vector delivery with semiconducting, biocompatible nanoparticles.

Journal/Review: NANOSCALE

Volume: 4 (4)      Pages from: 1271  to: 1274

More Information: The authors acknowledge Simone Nitti, lab technician, for ICP-OES measurement. SB, PW and AB thank German Research Foundation for funding within DFG excellence cluster REBIRTH.

DOI: 10.1039/c2nr11763k

Citations: 72
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