Towards bio-nanotransistors for electrical DNA sensing
Authors: Faglia G., Baratto C., Comini E., Ferroni M., Sberveglieri G., Andreano G., Cellai L., Flamini A., Marrazza G., Nannini A., Pennelli G., Piotto M.
Autors Affiliation: Dipartimento di Chimica e Fisica, CNR-INFM, Università di Brescia, Brescia, Italy; Istituto di Cristalografia, CNR, Rome, Italy; Istituto di Struttura della Materia, CNR, Rome, Italy; Dipartimento di Chimica, Università di Firenze, Firenze, Italy; Dipartimento Ingegneria dell\’Informazione, Università di Pisa, IEIIT CNR, Pisa, Italy
Abstract: We report on the innovative electrical detection of biological binding, based on a thin metal oxide (MOX) film as channel for a field effect transistor. The working principle relies on modulation of a MOX space charge region (SCR) instead of an enriched/depleted Si channel like in chem-FETs. The feasibility of the working principle was at first demonstrated by pH measurement in liquid. Afterwards we implemented a reliable protocol for the immobilization of ODNs and for the electrical detection of their hybridization. Work is in progress to scale MOX down to nanosized nanowire.
KeyWords: Electric wire; Field effect transistors; Metallic compounds; Metals; Nucleic acids; Organic acids; Sensors; Silicon, Biological binding; DNA sensing; Electrical detection; Nano wires; Nano-sized; Nano-transistors; PH measurements; Space-charge region; Thin metal oxide; Working principles, ModulationDOI: 10.1109/ICSENS.2007.355483