Neoplasms and metastasis detection in human blood exhalations with a device composed by nanostructured sensors
Authors: Landini N., Anania G., Fabbri B., Gaiardo A., Gherardi S., Guidi V., Rispoli G., Scagliarini L., Zonta G., Malagu C.
Autors Affiliation: [Landini, Nicolo; Fabbri, Barbara; Gaiardo, Andrea; Guidi, Vincenzo; Zonta, Giulia; Malagu, Cesare] Univ Ferrara, Dept Phys & Earth Sci, Off 109 Block C,Via Saragat 1-C, I-44122 Ferrara, Italy.
[Landini, Nicolo; Gherardi, Sandro] SCENT Srl, Via Quadrifoglio 11, I-44124 Ferrara, Italy.
[Anania, Gabriele; Scagliarini, Lucia] Univ Ferrara, Dept Morphol Surg & Expt Med, Via Luigi Borsari 46, I-44121 Ferrara, Italy.
[Gaiardo, Andrea] Bruno Kessler Fdn, Via Sommar 18, I-38123 Trento, Italy.
[Guidi, Vincenzo] CNR, INO, Largo Enrico Fermi 6, I-50124 Florence, Italy.
[Rispoli, Giorgio] Univ Ferrara, Dept Life Sci & Biotechnol, Via Luigi Borsari 46, I-44121 Ferrara, Italy.
Abstract: Nowadays, the demand for devices capable of efficiently identifying the presence of various biomarkers in human body, connected to a wide variety of pathologies, is progressively increasing. Chemoresistive semiconductor sensors, capable of changing their conductance depending on the chemical reactions between their surface and gaseous analytes, could be a suitable choice for medical devices implementation. In this work, a prototype based on an array of nanostructured sensors was tested, in order to detect the presence of airborne tumor markers in blood samples. These chemicals were conveyed to sensors with an air-flow circuit, equipped with antibacterial filters to maintain the sterility of the system. Resulting signals were acquired, processed and plotted thanks to a custom-made software, realized in Labview (R). Statistics on these signals was performed by means of Principal Component Analysis. Both male and female subjects, ranging between 21 to 91 years of age, have accepted to participate in this study, donating their blood samples. Donors were patients affected by colorectal and stomach cancers, at different stages of evolution, and/or having differently localized metastasis, and a healthy control group. The results have shown that the processed sensor responses, well discriminate healthy and tumor affected subjects. Obtained results can be also employed to assess the level of tumor growth and vascularization.
Journal/Review: SENSORS AND ACTUATORS. B, CHEMICAL (PRINT)
Volume: 271 Pages from: 203 to: 214