Scientific Results

Hyperspectral analysis applied to micro-Brillouin maps of amyloid-beta plaques in Alzheimer’s disease brains

Year: 2018

Authors: Palombo F.; Masia F.; Mattana S.; Tamagnini F.; Borri P.; Langbein W.; Fioretto D.

Autors Affiliation: University of Exeter, School of Physics and Astronomy, Exeter, EX4 4QL, United Kingdom; Cardiff University, School of Physics and Astronomy, Cardiff, CF24 3AA, United Kingdom; CNR-National Institute of Optics, Firenze, I-50125, Italy; University of Reading, School of Pharmacy, Reading, RG6 6LA, United Kingdom; Cardiff University, School of Biosciences, Cardiff, CF10 3AX, United Kingdom; University of Perugia, Department of Physics and Geology, Perugia, I-06100, Italy

Abstract: A recent investigation on the architecture and chemical composition of amyloid-ß (Aß) plaques in ex vivo histological sections of an Aß-overexpressing transgenic mouse hippocampus has shed light on the infrared light signature of cell-activation related biomarkers of Alzheimer

Journal/Review: ANALYST

Volume: 143 (24)      Pages from: 6095  to: 6102

More Information: This work was generously supported by the Wellcome Trust Institutional Strategic Support Award (WT105618MA). The animals were supplied by GlaxoSmithKline, as part of the European Union PharmacogIMI consortium.
KeyWords: Algorithms; Alzheimer Disease; Amyloid beta-Peptides; Animals; Elasticity; Hippocampus; Male; Mice, Transgenic; Microscopy, Confocal; Plaque, Amyloid; Viscosity
DOI: 10.1039/c8an01291a

Citations: 11
data from “WEB OF SCIENCE” (of Thomson Reuters) are update at: 2021-10-17
References taken from IsiWeb of Knowledge: (subscribers only)
Connecting to view paper tab on IsiWeb: Click here
Connecting to view citations from IsiWeb: Click here

gdpr-image
This site uses cookies. If you decide to continue browsing we consider that you accept their use. For more information about cookies and how to delete them please read our Info Policy on cookies use.
Read more