Observation of an improved healing process in superficial skin wounds after irradiation with a blue-LED haemostatic device

Year: 2016

Authors: Cicchi R., Rossi F., Alfieri D., Bacci S., Tatini F., De Siena G., Paroli G., Pini R., Pavone FS.

Autors Affiliation: National Institute of Optics, National Research Council (INO-CNR), Florence, 50125, Italy;
European Laboratory for Non-Linear Spectroscopy (LENS), University of Florence, Sesto Fiorentino, 50019, Italy;
Institute of Applied Physics, National Research Council (IFAC-CNR), Sesto Fiorentino, 50019, Italy;
Light4tech Firenze S.r.l., Scandicci, 50018, Italy;
Department of Clinical and Experimental Medicine, University of Florence, Florence, 50139, Italy;
Department of Physics, University of Florence, Sesto Fiorentino, 50019, Italy

Abstract: The healing process of superficial skin wounds treated with a blue-LED haemostatic device is studied. Four mechanical abrasions are produced on the back of 10 Sprague Dawley rats: two are treated with the blue-LED device, while the other two are left to naturally recover. Visual observations, non-linear microscopic imaging, as well as histology and immunofluorescence analyses are performed 8 days after the treatment, demonstrating no adverse reactions neither thermal damages in both abraded areas and surrounding tissue. A faster healing process and a better-recovered skin morphology are observed: the treated wounds show a reduced inflammatory response and a higher collagen content.

Journal/Review: JOURNAL OF BIOPHOTONICS

Volume: 9 (6)      Pages from: 645  to: 655

More Information: The research leading to these results has received funding from Tuscany Region and EU FP7 BiophotonicsPlus projects “LighTPatcH” (Led Technology in Photo Haemostasis) and “LITE” (Laser Imaging of The Eye), from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement number 284464, from the Italian Ministry of Health (GR-2011-02349626), from the Italian Ministry for Education, University and Research in the framework of the Flagship Project NANOMAX, from Fondazione Pisa, and from Ente Cassa di Risparmio di Firenze.
KeyWords: Engineering; Materials science; Photonics; Thermal effects, Blue light emitting diodes; Immunofluorescence analysis; Inflammatory response; Mechanical abrasion; Photocoagulation; Sprague-Dawley rats; Visual observations; Wound healing, Light emitting diodes, hemostatic agent, animal; injuries; light; phototherapy; rat; skin; Sprague Dawley rat; wound healing, Animals; Hemostatics; Light; Phototherapy; Rats; Rats, Sprague-Dawley; Skin; Wound Healing
DOI: 10.1002/jbio.201500191

Citations: 21
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