Scientific Results

Electro-Drawn Drug-Loaded Biodegradable Polymer Microneedles as a Viable Route to Hypodermic Injection

Year: 2014

Authors: Vecchione R., Coppola S., Esposito E., Casale C., Vespini V., Grilli S., Ferraro P., Netti P. A.

Autors Affiliation: Ist Nazl Ottica, Unita Napoli, I-80078 Pozzuoli Napoli, Italy; Ist Italiano Tecnol, Ctr Adv Biomat Hlth Care IIT CRIB, I-80125 Naples, Italy; Univ Naples Federico II, CRIB, I-80125 Naples, Italy

Abstract: Hypodermic needle injection is still the most common method of drug delivery despite its numerous limitations and drawbacks, such as pain, one-shot administration, and risk of infection. Seeking a viable, safe, and pain-free alternative to the over 16 billion injections per year has therefore become a top priority for our modern technological society. Here, a system that uses a pyroelectric cartridge in lieu of the syringe piston as a potential solution is discussed. Upon stimulation, the cartridge electro-draws, at room temperature, an array of drug-encapsulated, biodegradable polymer microneedles, able to deliver into hypodermic tissue both hydrophobic and hydrophilic bioactive agents, according to a predefined chrono-programme. This mould-free and contact-free method permits the fabrication of biodegradable polymer microneedles into a ready-to-use configuration. In fact, they are formed on a flexible substrate/holder by drawing them directly from drop reservoirs, using a controlled electro-hydrodynamic force. Tests of insertion are performed and discussed in order to demonstrate the possibility to prepare microneedles with suitable geometric and mechanical properties using this method.


Volume: 24 (23)      Pages from: 3515  to: 3523

DOI: 10.1002/adfm.201303679

Citations: 65
data from “WEB OF SCIENCE” (of Thomson Reuters) are update at: 2022-01-23
References taken from IsiWeb of Knowledge: (subscribers only)
Connecting to view paper tab on IsiWeb: Click here
Connecting to view citations from IsiWeb: Click here

This site uses cookies. If you decide to continue browsing we consider that you accept their use. For more information about cookies and how to delete them please read our Info Policy on cookies use.
Read more