Scientific Results

The connectomics challenge

Year: 2013

Authors: Silvestri L., Sacconi L., Pavone FS.

Autors Affiliation: European Laboratory for Nonlinear Spectroscopy (LENS) University of Florence, Italy; National Institute of Optics (INO-CNR), Sesto Fiorentino, Italy; Department of Physics, University of Florence, Italy; International Center for Computational Neurophotonics — ICON Foundation, Florence, Italy

Abstract: One of the most fascinating challenges in neuroscience is the reconstruction of the connectivity map of the brain. Recent years have seen a rapid expansion in the field of connectomics, whose aim is to trace this map and understand its relationship with neural computation. Many different approaches, ranging from electron and optical microscopy to magnetic resonance imaging, have been proposed to address the connectomics challenge on various spatial scales and in different species. Here, we review the main technological advances in the microscopy techniques applied to connectomics, highlighting the potential and limitations of the different methods.
Finally, we briefly discuss the role of connectomics in the Human Brain Project, the Future and Emerging Technologies (FET) Flagship recently approved by the European Commission.

Journal/Review: FUNCTIONAL NEUROLOGY

Volume: 28 (3)      Pages from: 167  to: 173

KeyWords: brain imaging; connectomics; electron microscopy; light microscopy; Human Brain Project
DOI: 10.11138/FNeur/2013.28.3.167

Citations: 10
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English