Preventive screening of colorectal cancer with a device based on chemoresistive sensors
Authors: Zonta G., Anania G., Fabbri B., Gaiardo A., Gherardi S., Giberti A., Landini N., Malagu C., Scagliarini L., Guidi V.
Autors Affiliation: Univ Ferrara, Dept Phys & Earth Sci, Via Saragat 1-c, I-44122 Ferrara, Italy; MIST E R Scrl, Via P Gobetti 101, I-40129 Bologna, Italy; CNR, INO, Largo Enrico Fermi 6, I-50124 Florence, Italy; Univ Ferrara, Dept Morphol Surg & Expt Med, Via Luigi Borsari 46, I-44121 Ferrara, Italy; Bruno Kessler Fdn, MNF, Via Sommarive 18, I-38123 Trento, Italy
Abstract: Colorectal cancer is one of the widely diffused tumors. Despite its high curable rate, if diagnosed in its polyp state, an efficient screening method is highly desirable for preventing and decreasing deaths. Tumor biomarkers, emitted by the peroxidation of the cell membrane, may alter the composition of feces. We developed an array of chemoresistive sensors (both metal oxides and sulfides) capable of distinguishing between real stool samples of healthy subjects and of patients with colorectal cancer at diverse degeneration stages. Preliminary clinical validation of real samples was carried out. Results have shown the selectivity of the sensor array towards tumor affected and healthy subject samples. A quadratic discriminant analysis was performed, with a classification error of about 5%. (C) 2016 Elsevier B.V. All rights reserved.
Journal/Review: SENSORS AND ACTUATORS. B, CHEMICAL (PRINT)
Volume: 238 Pages from: 1098 to: 1101
KeyWords: VOC; Colorectal cancer; Polyps; Chemoresistive sensors; Biomarkers; ScreeningDOI: 10.1016/j.snb.2016.07.079Citations: 11data from “WEB OF SCIENCE” (of Thomson Reuters) are update at: 2022-05-22References taken from IsiWeb of Knowledge: (subscribers only)Connecting to view paper tab on IsiWeb: Click hereConnecting to view citations from IsiWeb: Click here