Collagen ultrastructural symmetry and its malignant alterations in human breast cancer revealed by Polarization SHG microscopy

Year: 2020

Authors: Mercatelli R., Triulzi T., Pavone FS., Orlandi R., Cicchi R.

Autors Affiliation: National Institute of Optics, National Research Council (CNR-INO), Sesto Fiorentino, Italy; Aerospazio Tecnologie s.r.l., Italy; Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; Department of Physics, University of Florence, Sesto Fiorentino, Italy; European Laboratory for Non-linear Spectroscopy (LENS), Sesto Fiorentino, Italy

Abstract: Several specific alterations of the extracellular matrix can be considered a distinctive hallmark of cancer. In particular, a different morphology of the collagen scaffold is frequently found within the peritumoural environment. In this study, we report about a significant difference in the ultrastructural organization of collagen at the supramolecular
level between the perilesional scaffold and the tumour area in human breast carcinoma samples. In particular, we demonstrated that polarizationresolved second-harmonic generation (P-SHG) microscopy is able to link the altered collagen architecture at the ultrastructural level found in perilesional tissue with a different organization of collagen fibrils at the molecular level.


Volume: 13 (8)      Pages from: e202000159  to: e202000159

KeyWords: breast cancer, collagen, polarization, SHG microscopy
DOI: 10.1002/jbio.202000159

Citations: 14
data from “WEB OF SCIENCE” (of Thomson Reuters) are update at: 2022-09-25
References taken from IsiWeb of Knowledge: (subscribers only)
Connecting to view paper tab on IsiWeb: Click here
Connecting to view citations from IsiWeb: Click here