Scientific Results

Advanced multimodal laser imaging tool for urothelial carcinoma diagnosis (AMPLITUDE)

Year: 2020

Authors: Kurilchik S., Gacci M., Cicchi R., Pavone FS., Morselli S., Serni S., Chou MH., Narhi M., Rafailov E., Stewart N., Lennon C., Gumenyuk R.

Autors Affiliation: 1 Aston Institute of Photonic Technologies (AIPT), Aston University, Birmingham, United Kingdom
2 Careggi Hospital, University of Florence, Department of Minimally Invasive and Robotic Urological Surgery and Kidney
Transplantation, Florence, Italy
3 National Institute of Optics, National Research Council (INO-CNR), Sesto Fiorentino, Italy
4 European Laboratory for Non-linear Spectroscopy (LENS), Sesto Fiorentino, Italy
5 Department of Physics, University of Florence, Sesto Fiorentino, Italy
6 HC Photonics Corp, Hsinchu City, Taiwan
7 Laboratory of Photonics, Tampere University, Tampere, Finland
8 Modus Research and Innovation, Dundee, United Kingdom

Abstract: Bladder cancer (BC) is the eleventh most diagnosed cancer worldwide. The age-standardized incidence rate
(per 100 000 person/years) is 9.0 for men and 2.2 for women [1]. Urothelial carcinoma (UC) represents
about 90% of all bladder tumors, thus carrying an enormous social and economic burden [2]. UCs are
classified in different stages and grades, depending on their invasiveness and on their degree of cytological
abnormalities. The key aspect for a positive prognosis is the early and accurate diagnosis of the lesion stage,
in order to identify the most aggressive disease forms and treat them promptly. It is well known that tissue
metabolism constitutes a basic mechanism, which is at the base of many pathologies, especially BC. Being
able to detect and characterize tissue metabolism and molecular fingerprints at the cellular level could be a
key aspect in characterizing the pathology and enabling both early detection and therapy monitoring.
The new European Union Horizon 2020 project called AMPLITUDE, the ‘Advanced Multimodal
Photonics Laser Imaging Tool for Urothelial Diagnosis in Endoscopy’, starting in January 2020, proposes the
development of an advanced multi-modal imaging tool exploiting new laser technologies in an approach
combining confocal and non-linear imaging to fulfil unmet clinical needs in terms of the specificity and
accuracy of urothelial cancer diagnosis and therapy monitoring. The project is coordinated by Tampere
University (Finland) and carried out in cooperation with leading European research organizations including
Aston Insitute of Photonic Technologies—AIPT (UK), Consiglio Nazionale delle Ricerche—CNR (Italy),
Institute of Photonic Sciences—ICFO (Spain), University of Milan-Bicocca, Modus Research and Innovation
Ltd. (UK) and University of Florence (Italy), as well as industrial partners: Ampliconyx Oy (Finland),
Femtonics Ltd. (Hungary), HC Photonics (Taiwan), and LEONI Fiber Optics GmbH (Germany).

Journal/Review:

Volume: 2      Pages from: 021001  to: 021001

KeyWords: 3rd biological window, short-pulsed laser, bladder cancer, multiphoton imaging, confocal microscopy
DOI: https://doi.org/10.1088/2515-7647/ab7bab