Blue LED light modulates inflammatory infiltrate and improves the healing of superficial wounds

Year: 2020

Authors: Magni G., Tatini F., Bacci S., Paroli G., De Siena G., Cicchi R., Pavone FS., Pini R., Rossi F.

Autors Affiliation: Institute of Applied Physics, National Research Council (IFAC-CNR), Sesto Fiorentino, Italy
Department of Biology, University of Florence, Florence, Italy
National Institute of Optics, National Research Council (INO-CNR), Florence, Italy
European Laboratory for Non-Linear Spectroscopy (LENS), University of Florence, Sesto Fiorentino, Italy
Department of Physics, University of Florence, Sesto Fiorentino, Italy

Abstract: Previously published studies have evidenced that the blue LED light (420 nm) irradiation of superficial wounds is capable of inducing hemostasis by means of a photo-thermo-coagulation process: Light absorption by means of hemoglobin triggers a local increase in temperature, thus leading to a coagulative effect. During the follow-up studies, we observed a better organization of the collagen in the wound bed and a faster healing process, one that could be ascribed to photo effects rather than to a photo thermal one, for example, to photochemical effects. In addition to hemoglobin, other macromolecules, such as cytochromes, absorb blue light. After irradiation, these ubiquitous cellular components are able to trigger one or more intracellular pathways that can modulate the healing process.


Volume: 36 (2)      Pages from: 166  to: 168

More Information: The authors acknowledge financial support from the University of Florence and from the Fondazione Ente Cassa di Risparmio.
KeyWords: blue light, photo-bio-modulation, superficial wounds, wound healing
DOI: 10.1111/phpp.12527

Citations: 12
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