Monte Carlo application based on GEANT4 toolkit to simulate a laser-plasma electron beam line for radiobiological studies

Year: 2015

Authors: Lamia D., Russo G., Casarino C., Gagliano L., Candiano GC., Labate L., Baffigi F., Fulgentini L., Giulietti A., Koester P., Palla D., Gizzi LA., Gilardi M.C.

Autors Affiliation: CNR, LATO, IBFM, Inst Mol Biaimaging & Physiol, Cefalu, Italy; CNR, INO, ILIL, I-56100 Pisa, Italy; CNR, IBFM, Inst Mol Bioimaging & Physiol, Segrate, Italy; Univ Milano Bicocca, Milan, Italy; Ist Nazl Fis Nucl, Natl Inst Nucl Phys, Pisa Sect, Milan, Italy; Frascati Natl Labs, Milan, Italy.

Abstract: We report on the development of a Monte Carlo application, based on the CEANT4 toolkit, for the characterization and optimization of electron beams for clinical applications produced by a laser driven plasma source. The CEANT4 application is conceived so as to represent in the most general way the physical and geometrical features of a typical laser driven accelerator. It is designed to provide standard dosimeiric figures such as percentage dose depth curves, two-dimensional dose distributions and 3D dose profiles at different positions both inside and outside the interaction chamber. The application was validated by comparing its predictions to experimental measurements carried out on a real laser driven accelerator. The work is aimed at optimizing the source, by using this novel application, for radio biological studies and, in perspective, for medical applications. (C) 2015 Elsevier B.V. All rights reserved.

Journal/Review: NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT

Volume: 786      Pages from: 113  to: 119

More Information: This work was supported by FIRB/MERIT (RBNE089KHH). The activity of the INO-CNK Pisa group was partially supported from the Italian Ministry of Health through the Project no. GR-2009-1608935 (Study of Radiobiological and Radiotherapic Effects of a Novel Laser-Driven Electron Accelerator, D.I. AgeNaS), from the CNR funded Italian research Network ELI-Italy (Attoseconds) and from the PRIN project (Contract no. PRIN2012AY5LEL). The Pisa authors also acknowledge contribution from the MIUR-FIRB project SPARX (Sorgente Pulsata Auto-Amplificata di Radiazione X) and the INFN Plasma-med collaboration.
KeyWords: GEANT4; Laser driven beams; IOERT; Medical applications;
DOI: 10.1016/j.nima.2015.03.044

Citations: 6
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