Gold nanoparticles are suitable cores for building tunable iminosugar multivalency

Year: 2015

Authors: Matassini C., Marradi M., Cardona F., Parmeggiani C., Robina I., Moreno-Vargas A. J., Penadés S., Goti A.

Autors Affiliation: Univ Firenze, Dipartimento Chim Ugo Schiff, I-50019 Sesto Fiorentino, FI, Italy; CIC BiomaGUNE, Biofunct Nanomat Unit, Lab GlycoNanoTechnol, San Sebastian, Spain; CIBER BBN, San Sebastian 20009, Spain; CNR INO, I-50019 Sesto Fiorentino, FI, Italy; LENS, I-50019 Sesto Fiorentino, FI, Italy; Univ Seville, Fac Quim, Dept Quim Organ, E-41012 Seville, Spain.

Abstract: The first example of iminosugars multimerization based on gold nanoparticle cores was achieved by a straightforward synthetic strategy based on the use of simple glycosides of alpha-D-mannose or beta-Dglucose to modulate the density of biologically active pyrrolizidine and piperidine iminosugars at the gold surface. Exceptionally small and water dispersible gold colloids were obtained by self assembly of thiol ending sugar and novel iminosugar conjugates on the surface of in situ forming gold nanoparticles. The resulting nanostructures were characterized by different techniques. Preliminary screenings demonstrated that the novel nanosized architectures retain their bioactivity and make possible its modulation.

Journal/Review: RSC ADVANCES

Volume: 5 (116)      Pages from: 95817  to: 95822

More Information: We thank MIUR-Italy (PRIN 2010-2011, 2010L9SH3K 006), Ministero della Salute/Regione Toscana (Ricerca Finalizzata, RF-2011-02347694), MINECO (Spain, CT2011-27268) and the Ministerio de Economia y Competitividad (Spain, CTQ 201231247) for financial support. CM thanks Ente Cassa di Risparmio di Firenze (2013/0366) for a fellowship and the Basque Department of Economical Development and Competitiveness for cofinancing her PhD fellowship.
KeyWords: Self-assembled Monolayers; Carbohydrate-processing Enzymes; Glycosidase Inhibition; Click Clusters; Pharmacological Chaperones; Gaucher-disease; Glyconanoparticles; Ligands; Binding; Pyrrolizidine
DOI: 10.1039/c5ra22152h

Citations: 17
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