Analysis of genomic patchiness of Haemophilus influenzae and Saccharomyces cerevisiae chromosomes

Year: 1996

Authors: Lio P., Politi A., Ruffo S., Buiatti M.

Autors Affiliation: CRC Human Genetic Department, Princess Anne Hospital, University of Southampton, Southampton, U.K.; Istituto Nazionale di Ottica, Largo E. Fermi 6, 50125 Firenze, Italy; Dipartimento di Energetica, Universitą di Firenze, Via S. Marta 3, 50139 Firenze, Italy; Dipartimento di Biologia Animale e Genetica, Universitą di Firenze, Via Romana 17, 50125 Firenze, Italy; INFN e INFM, Firenze, Italy

Abstract: We have analysed some aspects of the primary structure of the chromosome of the prokaryote Haemophilus influenzae and of the eukaryote Saccharomyces cerevisiae that share the same G + C content. In particular, we have investigated genomic patchiness over the gene size level (10 Kb) and that patchiness due to long homogeneous tracts. Long polypurine and polypyrmidine tracts that are largely over-represented in S. cerevisiae chromosomes and under-represented in H. influenzae, are responsible for a large fraction of long correlation signals. Generating mechanisms of long homogeneous tracts are DNA replication slippage and duplication events that appear to be linked processes driving chromosome primary structure evolution. (C) 1996 Academic Press Limited

Journal/Review: JOURNAL OF THEORETICAL BIOLOGY

Volume: 183 (4)      Pages from: 455  to: 469

More Information: This work is part of the activity sponsored by INFM Forum Pisa and Firenze
KeyWords: Stepwise Mutation Model; Meiotic Recombination; Nucleotide-sequences; Codon Reiteration; Polypurine Tract; Universal Rule; Dna-sequence; Evolution; Organization; Replication
DOI: 10.1006/jtbi.1996.0235

Citations: 11
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