Magnetic field based investigation of Brugada syndrome

Year: 2026

Authors: Nicoletti M., Crispino A., Loppini A., Gizzi L.A., Chiodo L., Cherubini C., Filippi S.

Autors Affiliation: Univ Campus Biomed Roma, Dept Engn, Via Alvaro Portillo 21, I-00128 Rome, Italy; Ist Italiano Tecnol, Ctr Life Nano & Neuro Sci, Viale Regina Elena,291, I-00161 Rome, Italy; Univ Campus Biomed Roma, Dept Med & Surg, Via Alvaro Portillo 21, I-00128 Rome, Italy; Univ Campus Biomed Roma, Dept Sci & Biotechnol, Via Alvaro Portillo 21, I-00128 Rome, Italy; CNR, Ist Nazl Ott, Largo Enrico Fermi, I-50125 Florence, Italy; ICRANet Int Ctr Relativist Astrophys Network, Piazza Repubbl,10, I-65122 Pescara, Italy.

Abstract: Brugada syndrome (BrS) is an inherited cardiac disorder associated with and increased risk of sudden cardiac death. The syndrome is associated with a complex current distribution and repolarization dispersion. The traditional methods for the diagnosis rely on standard electrocardiographic (ECG) assessment of the cardiac dynamics. Recent advancements in magnetocardiography suggest that the magnetic-field based investigation of cardiac electrophysiology could offer novel perspectives for the investigation of current abnormalities in BrS patients which go beyond the conventional ECG capabilities to capture intricate current distributions. In this work, we propose a framework for the magnetic analysis of action potential disturbances in Brugada syndrome. We exploit a 1D reduced-order cable geometry for analyzing the relation between the pathological electrical activity in saddleback and coved type BrS and the corresponding magnetic field. Also, we compute transmural pseudo-magnetocardiograms and demonstrate their capabilities of detecting both types of BrS. Overall, our result highlight the potential of magnetic-field oriented investigation of cardiac disturbances related to BrS.

Journal/Review: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

More Information: This research has been funded by the European Commission-EU under the HORIZON Research and Innovation Action MUQUABIS GA n. 101070546, and by the European Union – NextGeneration EU, within PRIN 2022, PNRR M4C2, Project QUASAR 20225HYM8N [CUP C53D2300140 0008]. S.F. acknowledges the International Center for Relativistic Astrophysics Network – ICRANet. Authors wish to acknowledge the Italian National Group for Mathematical Physics, GNFM-INdAM.
KeyWords: Cardiac alternans; Magnetic-field; Brugada; Magnetocardiogram
DOI: 10.1007/s00249-026-01826-7