Real-Time Dose Monitoring via Non-Destructive Charge Measurement of Laser-Driven Electrons for Medical Applications
Year: 2025
Authors: Gregocki D., Koester P., Labate L.U., Piccinini S., Avella F., Baffigi F., Bandini G., Brandi F., Fulgentini L., Palla D., Salvadori M., Vlachos S.G., Gizzi L.A.
Autors Affiliation: CNR, Natl Inst Opt, Intense Laser Irradiat Lab, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy; Univ Pisa, Dept Phys, Largo Bruno Pontecorvo 3, I-56127 Pisa, Italy; Natl Inst Nucl Phys INFN, Pisa Sect, Largo Bruno Pontecorvo 3, I-56127 Pisa, Italy.
Abstract: Laser-accelerated electron beams, in the so-called Very High-Energy Electron (VHEE) energy range, are of great interest for biomedical applications. For instance, laser-driven VHEE beams are envisaged to offer suitable compact accelerators for the promising field of FLASH radiotherapy. Radiobiology experiments carried out using laser-driven beams require the real-time knowledge of the dose delivered to the sample. We have developed an online dose monitoring procedure, using an Integrating Current Transformer (ICT) coupled to a suitable collimator, that allows the estimation of the delivered dose on a shot-to-shot basis under suitable assumptions. The cross-calibration of the measured charge with standard offline dosimetry measurements carried out with RadioChromic Films (RCFs) is discussed, demonstrating excellent correlation between the two measurements.
Journal/Review: INSTRUMENTS
Volume: 9 (4) Pages from: 25-1 to: 25-13
More Information: The authors acknowledge funding from the European Union’s Horizon Europe research and innovation program and the UKRI guarantee funds through the MSCA EuPRAXIA Doctoral Network-EuPRAXIA-DN, under Grant Agreement No. 101073480, and additional financial support from the following research programs: EU Horizon 2020 Research and Innovation Program EuPRAXIA Preparatory Phase, under Grant Agreement No. 101079773, and EU Horizon IFAST, under Grant Agreement No. 101004730. This research has been co-funded by the European Union-NextGeneration EU through the Italian PNRR MUR projects Integrated infrastructure initiative in Photonic and Quantum Sciences-I-PHOQS (IR0000016, ID D2B8D520, CUP B53C22001750006); EuPRAXIA Advanced Photon Sources-EuAPS (IR0000030, CUP I93C21000160006); Tuscany Health Ecosystem(THE)-Spoke 1: Advanced Radiotherapies and Diagnostics in Oncology (ECS00000017, D.D. MUR No. 1055 23 May 2022); and the Italian INFN CSN5-funded project FRIDA.KeyWords: laser plasma acceleration; real-time dose monitoring; integrating current transformer; radiochromic films; very high-energy electron beamsDOI: 10.3390/instruments9040025
