A review of label-free photonics-based techniques for cancer detection in the digestive and urinary systems
Year: 2025
Authors: Castro-Olvera G., Baria E., Stoliarov D., Morselli S., Orlandini B., Vanoni M., Sayinc H., Koviarov A., Galiakhmetova D., Dickie J., Cicchi R., Serni S., Gacci M., Ribal M.J., Pavone F.S., Loza-Alvarez P., Rafailov E., Gumenyuk R.
Autors Affiliation: Barcelona Inst Sci & Technol, ICFO Inst Ciencies Foton, Barcelona, Spain; Natl Res Council CNR INO, Natl Inst Opt, I-56124 Pisa, Italy; LENS European Lab Nonlinear Spect, I-50125 Florence, Italy; Aston Univ, Birmingham, England; Careggi Univ Hosp, Careggi, Italy; Univ Florence, Florence, Italy; Careggi Univ Hosp, Unit Gastroenterol, Florence, Italy; Univ Milano Bicocca, ISBE Italy, Milan, Italy; ISBE Italy, SYSBIO, Milan, Italy; LEONI Fiber Opt GmbH, D-12459 Foritztal, Germany; Modus Res & Innovat, Dundee, Scotland; Univ Barcelona, Barcelona, Spain; Univ Florence, Dept Phys, I-50019 Sesto Fiorentino, Italy; Tampere Univ, Tampere, Finland.
Abstract: For a long time, it has been known that optics can provide a broad range of tools for addressing clinical needs, particularly diagnostics. Optical techniques can help in identifying diseases and detecting pathological tissues with non/minimally invasive and label-free methods. Given the current limitations of standard clinical procedures, such an approach could provide a powerful tool in detecting gastrointestinal and bladder cancers. However, each technique has serious limitations regarding one or more of the following features: biomarker sensitivity, penetration depth, acquisition times, or adaptation to the clinical environment. Hence there is an increasing need for approaches and instruments based on the concept of multimodality; in this regard, we review the application of different imaging/spectroscopy tools and methods operating in the first two optical windows (SHG, SPEF, TPEF, THG, 3PEF, CARS, Raman and reflectance) for tumour detection in the digestive and urinary systems. This article also explores the possibility of exploiting the third bio-tissue transmission window (1600-1900 nm) by reviewing state of the art in ultrafast laser sources development. Finally, we summarize the most recent results in developing multiphoton endoscopes-a key element for clinical in vivo translation of photonics-based diagnostics.
Journal/Review: JOURNAL OF PHYSICS-PHOTONICS
Volume: 7 (1) Pages from: 12002-1 to: 12002-25
More Information: This project has received funding from the European Union’s Horizon 2020 research and innovation programme under Grant Agreement No 871277 and is an initiative of the Photonics Public Private Partnership. G C O and P L A acknowledge funding form the Spanish Ministry of Economy and Competitiveness through the ’Severo Ochoa’ program for Centres of Excellence in R&D (CEX2019-000910-S), from Fundacio Privada Cellex, Fundacio Mir-Puig, Generalitat de Catalunya through the CERCA program and Laserlab-Europe EU-H2020 (871124). RG acknowledges Research Council of Finland (320165). G C-O, E B and D S, contributed data analysis, manuscript preparation, writing and revising. A K and D G contributed to data analysis. All authors contributed to manuscript writing and revision. D J, R C, S M, E R, F S P, M V, P L A, R G contributed project conceptualization supervision and funding.KeyWords: label-free; cancer diagnostic; SHG; Raman; TPEF; microscopyDOI: 10.1088/2515-7647/ad8613Citations: 1data from “WEB OF SCIENCE” (of Thomson Reuters) are update at: 2025-05-18References taken from IsiWeb of Knowledge: (subscribers only)
