Magnetic signature of thermoelectric cardiac dynamics

Year: 2025

Authors: Crispino A., Nicoletti M., Loppini A., Gizzi A., Chiodo L., Cherubini C., Filippi S.

Autors Affiliation: Univ Campus Biomed Roma, Dept Engn, I-00128 Rome, Italy; Italian Inst Technol, Ctr Life Nano & Neuro Sci CLN2S Sapienza, I-00161 Rome, Italy; Univ Campus Biomed Roma, Dept Med & Surg, I-00128 Rome, Italy; Ist Nazl Ottica Consiglio Nazl Ric CNR INO, I-50125 Florence, Italy; Univ Campus Biomed Roma, Dept Sci & Technol Sustainable Dev & One Hlth, I-00128 Rome, Italy.

Abstract: Developing methods to predict electromagnetic instabilities in cardiac dynamics is crucial. However, a comprehensive view of the heart’s magnetic activity at a tissue scale is still needed. To address such a challenging problem, we present a theoretical framework to investigate thermoelectric cardiac dynamics from the magnetic field perspective. Our framework demonstrates that periodic stimulations of cardiac cell strands create an external magnetic field, revealing predictable features of nonlinear spatiotemporal cardiac dynamics. Magnetic restitution curves better discriminate instabilities and bifurcations through a thermo-electro-magnetic map analysis. This new approach lays the foundation for innovative, noninvasive diagnostic tools for cardiac arrhythmias.

Journal/Review: PHYSICAL REVIEW E

Volume: 111 (1)      Pages from: L012401-1  to: L012401-6

More Information: This research was funded by the European Commission-EU under the HORIZON Research and Innovation Action MUQUABIS GA No. 101070546, and by the European Union-NextGeneration EU, within PRIN 2022, PNRR M4C2, Project QUASAR 20225HYM8N [CUP C53D2300140 0008] . The authors wish to acknowledge the Italian National Group for Mathematical Physics, GNFM-INdAM. C.C. and S.F. wish to acknowledge ICRA and ICRANet.
KeyWords: Ventricular-fibrillation; Spiral Breakup; Alternans; Mechanisms; Temperature; Hypothermia; Physics; Model; Field
DOI: 10.1103/PhysRevE.111.L012401