Modeling of olfactory transduction in AWCON neuron via coupled electrical-calcium dynamics
Year: 2023
Authors: Nicoletti M., Luchetti N., Chiodo L., Loppini A., Folli V., Ruocco G., Filippi S.
Autors Affiliation: Campus Biomed Univ, Dept Engn, Rome, Italy; Italian Inst Technol, Ctr Life Nano & Neurosci CLN2S Sapienza, Rome, Italy; D Tails Srl, Via Torre Rossa 66, I-00165 Rome, Italy; Consiglio Nazl Ric CNR INO, Ist Nazl Ott, Florence, Italy.
Abstract: Amphid wing C (AWC) neurons are among the most important and studied neurons of the nematode Caenorhabditis elegans. In this work, we unify the existing electrical and intracellular calcium dynamics descriptions to obtain a biophysically accurate model of olfactory transduction in AWC(ON) neurons. We study the membrane voltage and the intracellular calcium dynamics at different exposure times and odorant concentrations to grasp a complete picture of AWC(ON) functioning. Moreover, we investigate the complex cascade of biochemical processes that allow AWC activation upon odor removal. We analyze the behavior of the different components of the models and, by suppressing them selectively, we extrapolate their contribution to the overall neuron response and study the resilience of the dynamical system. Our results are all in agreement with the available experimental data. Therefore, we provide an accurate mathematical and biophysical model for studying olfactory signal processing in C. elegans.
Journal/Review: BIOMOLECULAR CONCEPTS
Volume: 14 (1) Pages from: 20220035-1 to: 20220035-13
More Information: The authors acknowledge Valeria Lucente Davide Caprini, and Enrico Lanza for providing the raw experimental data shown in Figure 3. M.N., N.L., L.C., A.L., S.F. acknowledge the support from the IR0000011 – EBRAINS-Italy PNRR research infrastructure, and from the Italian National Group for Mathematical Physics (GNFM-INdAM). A.L., L.C. and S.F. acknowledge the support of the International Center for Relativistic Astrophysics Network (ICRANet), Italy.KeyWords: C. elegans; olfaction modeling; AWC(ON) neuronsDOI: 10.1515/bmc-2022-0035Citations: 1data from “WEB OF SCIENCE” (of Thomson Reuters) are update at: 2025-01-12References taken from IsiWeb of Knowledge: (subscribers only)