Chemoresistive Gas Sensors for the Detection of Colorectal Cancer Biomarkers

Year: 2014

Authors: Malagsch C., Fabbri B., Gherardi S., Giberti A., Guidi V., Landini N., Zonta G.

Autors Affiliation: Univ Ferrara, Dept Phys & Earth Sci, I-44122 Ferrara, Italy; CNR, INO, I-50124 Florence, Italy; MIST E R Scrl, I-40129 Bologna, Italy.

Abstract: Numerous medical studies show that tumor growth is accompanied by protein changes that may lead to the peroxidation of the cell membrane with consequent emission of volatile organic compounds (VOCs) by breath or intestinal gases that should be seen as biomarkers for colorectal cancer (CRC). The analysis of VOCs represents a non-invasive and potentially inexpensive preliminary screening technique. An array of chemoresistive gas sensors based on screen-printed metal oxide semiconducting films has been selected to discriminate gases of oncological interest, e. g., 1-iodononane and benzene, widely assumed to be biomarkers of colorectal cancer, from those of interference in the gut, such as methane and nitric oxide.

Journal/Review: SENSORS

Volume: 14 (10)      Pages from: 18982  to: 18992

KeyWords: gas; sensors; nanotechnology; semiconductors; metal oxides; colorectal cancer; VOC; 1-iodo-nonane
DOI: 10.3390/s141018982

Citations: 29
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