Drift and termination of spiral waves in optogenetically modified cardiac tissue at sub-threshold illumination

Year: 2021

Authors: Hussaini S., Venkatesan V., Biasci V., Sepulveda JMR., Uribe RAQ., Sacconi L., Bub G., Richter C., Krinski V., Parlitz U., Majumder R., Luther S.

Autors Affiliation: Max Planck Inst Dynam & Self Org, Res Grp Biomed Phys, Gottingen, Germany; Goettingen Univ, Inst Dynam Complex Syst, Gottingen, Germany; German Ctr Cardiovasc Res, Partner Site Goettingen, Gottingen, Germany; Univ Med Ctr Goettingen, Clin Cardiol & Pneumol, Gottingen, Germany; European Lab Nonlinear Spect, Sesto Fiorentino, FI, Italy; Univ Florence, Dept Expt & Clin Med, Div Physiol, Florence, Italy; MGill Univ, Dept Physiol, Montreal, PQ, Canada; Univ Freiburg, Inst Expt Cardiovasc Med, Freiburg, Germany; CNR, Natl Inst Opt, Florence, Italy; CNRS, INPHYNI, Paris, France; Univ Med Ctr Goettingen, Inst Pharmacol & Toxicol, Gottingen, Germany.

Abstract: The development of new approaches to control cardiac arrhythmias requires a deep understanding of spiral wave dynamics. Optogenetics offers new possibilities for this. Preliminary experiments show that sub-threshold illumination affects electrical wave propagation in the mouse heart. However, a systematic exploration of these effects is technically challenging. Here, we use state-of-the-art computer models to study the dynamic control of spiral waves in a two-dimensional model of the adult mouse ventricle, using stationary and non-stationary patterns of sub-threshold illumination. Our results indicate a light-intensity-dependent increase in cellular resting membrane potentials, which together with diffusive cell-cell coupling leads to the development of spatial voltage gradients over differently illuminated areas. A spiral wave drifts along the positive gradient. These gradients can be strategically applied to ensure drift-induced termination of a spiral wave, both in optogenetics and in conventional methods of electrical defibrillation.

Journal/Review: ELIFE

Volume: 10      Pages from: e59954-1  to: e59954-17

More Information: German Centre for Cardiovascular Research Stefan Luther; German Research Foundation SFB 1002 Modulatory Units in Heart Failure Stefan Luther; Max Planck Society Stefan Luther; The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
KeyWords: Excitation; Fibrillation; Shocks; Heart
DOI: 10.7554/eLife.59954

Citations: 42
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