Neurophotonic tools for microscopic measurements and manipulation: status report

Year: 2022

Authors: Abdelfattah AS., Ahuja S., Akkin T., Allu SR., Brake J., Boas DA., Buckley EM., Campbell RE., Chen AI., Cheng XJ., Cizmbr T., Costantini I., De Vittorio M., Devor A., Doran PR., El Khatib M., Emiliani V., Fomin-Thunemann N., Fainman Y., Fernandez-Alfonso T., Ferri CGL., Gilad A., Han X., Harris A., Hillman EMC., Hochgeschwender U., Holt MG., Ji N., Kiliz K., Lake EMR., Li L., Li TQ., Mdchler P., Miller EW., Mesquita RC., Nadella KMNS., Ndgerl UV., Nasu Y., Nimmerjahn A., Ondrbckovb P., Pavone FS., Campos CP., Peterka DS., Pisano F., Pisanello F., Puppo F., Sabatini BL., Sadegh S., Sakadzic S., Shoham S., Shroff SN., Silver RA., Sims RR., Smith SL., Srinivasan VJ., Thunemann M., Tian L., Tian L., Troxler T., Valera A., Vaziri A., Vinogradov SA., Vitale F., Wang LV., Uhlnrovb H., Xu C., Yang CHE., Yang MH., Yellen G., Yizhar O., Zhao YX.

Autors Affiliation: Brown Univ, Dept Neurosci, Providence, RI 02912 USA; Univ Penn, Dept Biochem & Biophys, Perelman Sch Med, Philadelphia, PA 19104 USA; Univ Penn, Dept Chem, Sch Arts & Sci, Philadelphia, PA 19104 USA; Univ Minnesota, Dept Biomed Engn, Minneapolis, MN USA; Harvey Mudd Coll, Dept Engn, Claremont, CA 91711 USA; Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA; Georgia Inst Technol, Atlanta, GA 30332 USA; Emory Univ, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30322 USA; Emory Univ, Dept Pediat, Atlanta, GA 30322 USA; Univ Tokyo, Dept Chem, Tokyo, Japan; Univ Alberta, Dept Chem, Edmonton, AB, Canada; Czech Acad Sci, Inst Sci Instruments, Brno, Czech Republic; Univ Florence, Dept Biol, European Lab Nonlinear Spect, Florence, Italy; CNR, Natl Inst Opt, Rome, Italy; Ist Italiano Tecnol, Ctr Biomol Nanotechnol, Arnesano, Italy; Harvard Med Sch, Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA; Sorbonne Univ, Inst Vis, CNRS, INSERM, Paris, France; Univ Calif San Diego, Dept Elect & Comp Engn, La Jolla, CA 92093 USA; UCL, Dept Neurosci Physiol & Pharmacol, London, England; Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA; Hebrew Univ Jerusalem, Fac Med, Inst Med Res Israel Canada, Dept Med Neurobiol, Jerusalem, Israel; Weizmann Inst Sci, Dept Brain Sci, Rehovot, Israel; Columbia Univ, Zuckerman Mind Brain Behav Inst, New York, NY USA; Cent Michigan Univ, Dept Neurosci, Mt Pleasant, MI 48859 USA; Univ Porto, Inst Invest & Inovacao Saude I3S, Porto, Portugal; Univ Calif Berkeley, Dept Phys, Berkeley, CA 94720 USA; Yale Sch Med, Dept Radiol & Biomed Imaging, New Haven, CT USA; CALTECH, Dept Elect Engn, Andrew & Peggy Cherng Dept Med Engn, Pasadena, CA USA; Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA; Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA; Helen Wills Neurosci Inst, Berkeley, CA USA; Univ Estadual Campinas, Inst Phys, Campinas, SP, Brazil; Univ Bordeaux, Interdisciplinary Inst Neurosci, Bordeaux, France; CNRS, Bordeaux, France; Salk Inst Biol Studies, Waitt Adv Biophoton Ctr, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA; Univ Florence, Dept Phys, European Lab Nonlinear Spect, Florence, Italy; Harvard Med Sch, Howard Hughes Med Inst, Dept Neurobiol, Boston, MA 02115 USA; NYU, Tech4Hlth Inst, Grossman Sch Med, New York, NY USA; NYU, Grossman Sch Med, Neurosci Inst, New York, NY USA; Univ Calif Santa Barbara, Dept Elect & Comp Engn, Santa Barbara, CA 93106 USA; New York Univ Langone Hlth, Dept Ophthalmol, New York, NY USA; New York Univ Langone Hlth, Dept Radiol, New York, NY USA; Boston Univ, Dept Elect Engn, Boston, MA 02215 USA; Univ Calif Davis, Dept Biochem & Mol Med, Davis, CA 95616 USA; Rockefeller Univ, Lab Neurotechnol & Biophys, 1230 York Ave, New York, NY 10021 USA; Rockefell er Univ, Kavli Neural Syst Inst, 1230 York Ave, New York, NY 10021 USA; Ctr Neuroengn & Therapeut, Dept Neurol, Philadelphia, PA USA; Ctr Neuroengn & Therapeut, Dept Bioengn, Philadelphia, PA USA; Ctr Neuroengn & Therapeut, Dept Phys Med & Rehabil, Philadelphia, PA USA; Cornell Univ, Sch Appl & Engn Phys, Ithaca, NY USA; CALTECH, Dept Elect Engn, Pasadena, CA 91125 USA; CALTECH, Dept Bioengn, Pasadena, CA USA; CALTECH, Dept Mech Engn, Pasadena, CA 91125 USA; Harvard Med Sch, Dept Neurobiol, Boston, MA 02115 USA; Carnegie Mellon Univ, Dept Biol Sci, 4400 5th Ave, Pittsburgh, PA 15213 USA; Varioscale Inc, San Marcos, CA USA; UCSD, Dept Phys, La Jolla, CA USA; UCSD, Dept Pediat, La Jolla, CA USA;

Abstract: Neurophotonics was launched in 2014 coinciding with the launch of the BRAIN Initiative focused on development of technologies for advancement of neuroscience. For the last seven years, Neurophotonics’ agenda has been well aligned with this focus on neurotechnologies featuring new optical methods and tools applicable to brain studies. While the BRAIN Initiative 2.0 is pivoting towards applications of these novel tools in the quest to understand the brain, this status report reviews an extensive and diverse toolkit of novel methods to explore brain function that have emerged from the BRAIN Initiative and related large-scale efforts for measurement and manipulation of brain structure and function. Here, we focus on neurophotonic tools mostly applicable to animal studies. A companion report, scheduled to appear later this year, will cover diffuse optical imaging methods applicable to noninvasive human studies. For each domain, we outline the current state-of-the-art of the respective technologies, identify the areas where innovation is needed, and provide an outlook for the future directions. (C) The Authors. Published by SPIE under a Creative Commons Attribution 4.0 International License.

Journal/Review: NEUROPHOTONICS

Volume: 9      Pages from: 13001-1  to: 13001-86

More Information: This report was edited by Anna Devor and Darcy Peterka. Cover design by Kvlcm Klc. A.D. was supported by the U.S. National Institutes of Health (NIH) grants R01MH111359, R01DA050159, and U19NS123717. A.N. was supported by NIH grants R01NS108034, U19NS112959, and U19NS123719. D.A.B. was supported by NIH grant R01NS108472. M.G.H. is currently the ERANet Chair (NCBio) at i3S Porto funded by the European Commission (H2020-WIDESPREAD-2018-2020-6; NCBio; 951923). R.A.S. is a Wellcome Principal Research Fellow (203048, 224499) and his microscopy development is co-funded by the NIH Brain initiative (U01NS113273). Fi.P., and Fe.P. acknowledge funding from the European Research Council under the European Union’s Horizon 2020 Research and Innovation Program under Grant Agreemen t No. 677683. M.D.V. and Fe.P. acknowledge funding from the European Union’s Horizon 2020 Research and Innovation Program under Grant Agreement No. 828972. Fi.P., M.D.V., Fe.P, O.Y., V.E., and T.C. acknowledge that this project has received funding from the European Union’s Horizon 2020 Research and Innovation Program under Grant Agreement No. 101016787. Fe.P., B.L.S., and M.D.V. were funded by NIH Grant No. 1UF1NS108177-01. O.Y. and V. E. were supported by H2020-RIA (DEEPER 101016787) and the ERC (PrefrontalMap 819496). L.V.W. acknowledges funding support by NIH grants R01 NS102213, U01 NS099717, and U01 EB029823. S.L.S. was supported by NIH grants R01NS091335, R01NS121919 and National Science Foundation (NSF) grant 1934288. R.E.C, and Y.N. were supported by Japan Society for the Promotion of Science (JSPS) KAKENHI grant 19H05633. V.J.S. was supported by NIH grants NS094681, EB029747, and EY031469. S.N.S. acknowledges funding from the NIH Ruth L. Kirschstein National Research Service Award (F31 NS115421). P.R.D. acknowledges funding from the NIH Ruth L. Kirschstein National Research Service Award (F31 NS118949). T.A. and T.L. acknowledge funding from the University of Minnesota Medical School (AIRP) and the National Ataxia Foundation. F.V. was supported by NIH grants R01NS117756 and R01NS121219. U.H. was supported by NIH Brain Initiative grants R01NS120832, U01NS099709, and NSF NeuroNex Technology Hub 1707352. G.Y. was supported by NIH grants R01 GM124038 and R01 NS102586. L. T. was funded by NIH grant R21EY030016. I.C. was supported by European Union’s Horizon 2020 Research and Innovation Framework Program under Grant Agreement No. 654148 (Laserlab-Europe); European Union’s Horizon 2020 Framework Programme for Research and Innovation under the Specific Grant Agreement No. 785907 (Human Brain Project SGA2) and No. 945539 (Human Brain Project SGA3); General Hospital Corporation Center of the NIH under Award No. U01 MH117023; Italian Ministry for Education in the framework of Euro-Bioimaging Italian Node (ESFRI research infrastructure); Fondazione CR Firenze (private foundation). T. ., H. U., and P. O. were supported by the European Union’s H2020-RIA (DEEPER, Grant Agreement No. 101016787), European Research Council (724530), and MEYS (CZ.02.1.01/ 0.0/ 0.0/ 15_003/0000476). S.S. was supported by NIH grants U19NS107464, R01NS109885 and UF1NS107680. V.E and R.S were supported by the European Research Council (ERC-2019-AdG 885090, HOLOVIS). N.J. was supported by NIH grant U01NS118300. A.V. was supported by the National Institute of Neurological Disorders and Stroke of the NIH under Award Nos. 5U01NS103488, 1RF1NS113251, and 1RF1NS110501, and the Kavli Foundation. D. S. P. was supported by NIH grants 5U19NS104649, 5U01NS113273, 9R44MH117430. Y. Z.; was supported by NIH Director’s New Innovator Award DP2 OD025926-01 and the Kaufman Foundation. A. S. A holds a Career Award at the Scientific Interface from Burroughs Wellcome Fund and acknowledges funding from the Searle Scholar Program and NIH New innovator award 1DP2MH129956. E. M. R. L. was supported by NIH grants R01MH111424 and U01NS094358. E. W. M. acknowledges support from NIH (R01NS098088) and NSF (NeuroNex 1707350).
KeyWords: optical imaging; molecular sensors; optogenetics; fluorescence; label free; blood flow; multimodal
DOI: 10.1117/1.NPh.9.S1.013001

Citations: 29
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