Ecofriendly Preparation of Rosmarinic Acid-poly(vinyl alcohol) Biofilms Using NADES/DES, Ultrasounds and Optimization via a Mixture-Process Design Strategy

Year: 2024

Authors: Campanella B., Simoncini M., Passaglia E., Cicogna F., Ciancaleoni G., Gonzalez-Rivera J., Bernazzani L., Bramanti E.

Autors Affiliation: Inst Chem Organometall Cpds, Natl Res Council, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy; Univ Pisa, Dept Chem & Ind Chem, Via Giuseppe Moruzzi 13, I-56124 Pisa, Italy; Natl Inst Opt, Natl Res Council, Via Giuseppe Moruzzi 1, I-56124 Pisa, Italy.

Abstract: Green chemistry emphasizes the isolation of biologically active compounds from plants and biomass to produce renewable, bio-based products and materials through sustainability and circularity-driven innovation processes. In this work, we have investigated the extraction of rosmarinic acid (RA), a phenolic acid with several biological properties, from aromatic herbs using ultrasounds and low environmental risk natural deep eutectic solvents (NADES). Various solvent mixtures have been investigated, and the parameters influencing the process have been studied by a mixture-process experimental design to identify the optimal RA extraction conditions. The extraction yield has been calculated by HPLC-diode array analysis. The lactic acid:ethylene glycol mixture using an ultrasound-assisted process has been found to be the most versatile solvent system, giving RA yields 127-160% higher than hydroalcoholic extraction (70% ethanol). The deep eutectic solvent nature of lactic acid:ethylene glycol has been demonstrated for the first time by multi-technique characterization (1H-NMR and 13C-NMR, DSC, and W absorption properties). The aqueous raw extract has been directly incorporated into poly(vinyl alcohol) to obtain films with potential antibacterial properties for applications in the field of food and pharmaceutical packaging.

Journal/Review: MATERIALS

Volume: 17 (2)      Pages from: 377-1  to: 377-16

More Information: The authors thank Regione Toscana POR FESR 2014-2020 for project FELIX (Fotonica ed Elettronica Integrate per l’Industria), Grant Number 6455, which partially funded the acquisition of the Horiba FluoroMax-4 spectrofluorometer.
KeyWords: NADES; rosmarinic acid; bioactive materials
DOI: 10.3390/ma17020377

Connecting to view paper tab on IsiWeb: Click here