Fluorescence detected circular dichroism (FDCD) of a stereodynamic probe

Year: 2023

Authors: Penasa R., Begato F., Licini G., Wurst K., Abbate S., Longhi G., Zonta C.

Autors Affiliation: Univ Padua, Dipartimento Sci Chim, Via Marzolo 1, I-35131 Padua, Italy; Univ Innsbruck, Dept Gen Inorgan & Theoret Chem, A-6020 Innsbruck, Austria; Univ Brescia, Dept Mol & Translat Med, Viale Europa 11, I-25123 Brescia, BS, Italy; CNR, Ist Nazl Ott INO, Res Unit Brescia, Via Branze 45, I-25123 Brescia, Italy.

Abstract: The use of chiroptical techniques in combination with stereodynamic probes is becoming one of the leading strategies for chiral sensing. While in most of the reported studies circular dichroism (CD) is the adopted spectroscopic technique, examples regarding the use of vibrational CD (VCD), circularly polarized luminescence (CPL), and Raman optical activity (ROA) are emerging as innovative tools. In this communication, an anthracene-decorated tris(2-pyridylmethyl)amine zinc complex (TPMA) is reported for its capability to act as a chiral sensor using either CD or fluorescence detected circular dichroism (FDCD). The latter technique offers the unique possibility to determine the enantiomeric excess of a series of carboxylic acids at sensor concentrations down to 0.1 mu M. Limitations and possibilities opened by the use of this methodology, in particular regarding the specificity of the probe in the presence of another contaminant, are discussed.

Journal/Review: CHEMICAL COMMUNICATIONS

Volume: 59 (44)      Pages from: 6714  to: 6717

KeyWords: Enantiomeric Excess; Chirality; Identity
DOI: 10.1039/d3cc01249b

Citations: 6
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