Langmuir-blodgett films of antibodies as mediators of endothelial cell adhesion on polyurethanes

Year: 1999

Authors: Ahluwalia A., Basta G., Ricci D., Francesconi R., Domenici C., Grattarola M., Palchetti L., Preininger C., Rossi D.D.

Autors Affiliation: Centro ’E. Piaggio’, University of Pisa, via Diotisalvi 2, Pisa, 56126, Italy; CNR Institute of Clinical Physiology, via Savi 8, Pisa, Italy; DIBE, University of Genova, via Opera Pia 11, Genova, Italy; IROE-CNR, via Panciatichi 64, Firenze, Italy

Abstract: The effect of endothelial cell adhesion on polyurethanes coated with Langmuir-Blodgett antibody films has been examined. The films were cross-linked with glutaraldehyde with the aim of providing a densely packed and covalently linked two-dimensional antibody network on the polyurethane surfaces. Our results demonstrate that although neither of the two polyurethanes examined were entirely suited to cellular adhesion, Langmuir-Blodgett antibody films, cross-linked with small concentrations of glutaraldehyde, are more suitable for endothelial cell adhesion than surfaces free of antibody.

Journal/Review: JOURNAL OF BIOMATERIALS SCIENCE. POLYMER

Volume: 10 (3)      Pages from: 295  to: 304

KeyWords: Antibody; glutaraldehyde; polyurethan, article; cell adhesion; cross linking; endothelium cell; priority journal
DOI: 10.1163/156856299X00360

Citations: 2
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