Adaptive tracking of enzymatic reactions with quantum light

Anno: 2019

Autori: Cimini V., Mellini M., Rampioni G., Sbroscia M., Leoni L., Barbieri M., Gianani I.

Affiliazione autori: Univ Roma Tre, Dipartimento Sci, Via Vasca Navale 84, I-00146 Rome, Italy; CNR, Ist Nazl Ott, Largo Enrico Fermi 6, I-50125 Florence, Italy; Sapienza Univ Roma, Dipartimento Fis, Ple Aldo Moro 5, I-00185 Rome, Italy

Abstract: Enzymes are essential to maintain organisms alive. Some of the reactions they catalyze are associated with a change in reagents chirality, hence their activity can be tracked by using optical means. However, illumination affects enzyme activity: the challenge is to operate at low-intensity regime avoiding loss in sensitivity. Here we apply quantum phase estimation to real-time measurement of invertase enzymatic activity. Control of the probe at the quantum level demonstrates the potential for reducing invasiveness with optimized sensitivity at once. This preliminary effort, bringing together methods of quantum physics and biology, constitutes an important step towards full development of quantum sensors for biological systems. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

Giornale/Rivista: OPTICS EXPRESS

Volume: 27 (24-25)      Da Pagina: 35245  A: 35256

Parole chiavi: PHASE ESTIMATION; LIMIT
DOI: 10.1364/OE.27.035245

Citazioni: 6
dati da “WEB OF SCIENCE” (of Thomson Reuters) aggiornati al: 2022-05-22
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