Proteomica/genomica/metabolomica per l’individuazione di biomarcatori e lo sviluppo di
una piattaforma di rivelazione ultrasensibile in fluidi corporei periferici: applicazione al
Calls: BANDO FAS SALUTE 2014
Start date: 2017-03-17 End date: 2019-03-16
Total Budget: EUR 950.359,31 INO share of the total budget: EUR 309.600,00
Scientific manager: Marco Cecchini and for INO is: Cicchi Riccardo
Organization/Institution/Company main assignee: Scuola Normale Superiore Classi di Scienze Matematiche e Naturali
other Organization/Institution/Company involved:
Fondazione Istituto Italiano di Tecnologia
other INO’s people involved:
Although there is currently no technology that allows early diagnosis of the disease, a number of putative markers have been identified: their detection after diagnosis would be a useful tool to monitor the evolution of the tumor during treatment, providing valuable prognostic information on response to a given therapy and helping doctors to separate patients in distinct therapeutic groups to allow them to be optimally treated (” personalized ”), and for rationalizing costs.
In this project we will promote the convergence between clinical, genomic / proteomic, molecular cell biology and nanotechnology to develop a new pioneering ultrasensitive device for the detection of biomarkers, both new and already known, for GBM in peripheral fluids.
Since this technology platform is designed to simultaneously detect multiple biomarkers, it has the potential for being used as a diagnostic tool for a wide variety of pathologies. For example, it is hypothesized that Alzheimer’s disease, the main cause of dementia, progress for decades largely without symptoms before diagnosis, and one of the crucial issues for effective treatments is to develop the technology needed to detect very low levels of biomarkers in the early stage of the disease. In addition, convergent tests performed on molecular blood analysis (Serum / plasma) revealed peripheral molecular changes even in major psychiatric disorders such as schizophrenia, epilepsy, depression, and bipolar disorders, suggesting that biomarkers can provide useful Diagnostic / Prognostic information related to these pathologies by detection in the circulating blood.
INO’s Experiments/Theoretical Study correlated:
Multimodal fibre-probe spectroscopy for tissue diagnostics
Multimodal microscopy for biological tissue imaging