Scientific Results

LESM: A laser-driven sub-MeV electron source delivering ultra-high dose rate on thin biological samples

Year: 2016

Authors: Labate L., Andreassi M.G., Baffigi F., Bizzarri R., Borghini A., Bussolino G.C., Fulgentini L., Ghetti F., Giulietti A., Köster P., Lamia D., Levato T., Oishi Y., Pulignani S., Russo G., Sgarbossa A., Gizzi L.A.

Autors Affiliation: Istituto Nazionale di Ottica, Consiglio Nazionale Delle Ricerche, Pisa, Italy; Istituto di Fisiologia Clinica, Consiglio Nazionale Delle Ricerche, Pisa, Italy; NEST, Istituto Nanoscienze, Consiglio Nazionale Delle Ricercheand Scuola Normale Superiore, Pisa, Italy; Istituto di Bioimmagini e Fisiologia Molecolare, Consiglio Nazionale Delle Ricerche, LATO, Cefalu, Italy; ELI-Beamlines, Institute of Physics, Czech Academy of Science, Prague, Czech Republic; Central Research Institute of Electric Power Industry, Kanagawa, Japan; Istituto Nazionale di Fisica Nucleare, Sezione di Pisa, Italy

Abstract: We present a laser-driven source of electron bunches with average energy 260 keV and picosecond duration, which has been setup for radiobiological tests covering the previously untested sub-MeV energy range. Each bunch combines high charge with short duration and sub-millimeter range into a record instantaneous dose rate, as high as 10(9) Gy s(-1). The source can be operated at 10 Hz and its average dose rate is 35 mGy s(-1). Both the high instantaneous dose rate and high level of relative biological effectiveness, attached to sub-MeV electrons, make this source very attractive for studies of ultrafast radiobiology on thin cell samples. The source reliability, in terms of shot-to-shot stability of features such as mean energy, bunch charge and transverse beam profile, is discussed, along with a dosimetric characterization. Finally, a few preliminary biological tests performed with this source are presented.

Journal/Review: JOURNAL OF PHYSICS D-APPLIED PHYSICS

Volume: 49 (27)      Pages from: 275401 -1  to: 275401 -9

More Information: The activity of the INO-CNR Pisa group was partially supported from the Italian Ministry of Health through the Project No. GR-2009-1608935 (Study of Radiobiological and Radiotherapic Effects of a Novel Laser-Driven Electron Accelerator, D.I. AgeNaS), from the CNR funded Italian research Network ELI-Italy (Attoseconds) and from the PRIN project (Contract No. PRIN2012AY5LEL). The Pisa authors also acknowledge contribution from the MIUR-FIRB project SPARX (Sorgente Pulsata Auto-Amplificata di Radiazione X) and the INFN gResist and Plasma-med collaborations.
KeyWords: Laser-driven electron accelerators; Sub-MeV electron sources; Ultrahigh dose rate; Radiobiology; Cell radiation damage
DOI: 10.1088/0022-3727/49/27/275401

English