Highly sensitive biosensors based on all-dielectric nanoresonators
Authors: Bontempi N., Chong K.E., Orton H.W., Staude I., Choi D.-Y., Alessandri I., Kivshar Y.S., Neshev D.N.
Autors Affiliation: Nonlinear Physics Centre, Research School of Physics and Engineering, Australian National University, Canberra, ACT 2601, Australia; INSTM and Chemistry for Technologies Laboratory, Mechanical and Industrial Engineering Department, University of Brescia, Brescia, 25123, Italy; Institute of Applied Physics, Abbe Center of Photonics, Friedrich Schiller University Jena, Jena, 07743, Germany; Laser Physics Centre, Research School of Physics and Engineering, Australian National University, Canberra, ACT 2601, Australia
Abstract: Biosensing based on nanophotonic structures has shown a great potential for cost-efficient, high-speed and compact personal medical diagnostics. While plasmonic nanosensors offer high sensitivity, their intrinsically restricted resonance quality factors and strong heating due to metal absorption impose severe limitations on real life applications. Here, we demonstrate an all-dielectric sensing platform based on silicon nanodisks with strong optically-induced magnetic resonances, which are able to detect a concentration of streptavidin of as low as 10-10 M (mol L-1) or 5 ng mL-1, thus pushing the current detection limit by at least two orders of magnitudes. Our study suggests a new direction in biosensing based on bio-compatible, non-toxic, robust and low-loss dielectric nanoresonators with potential applications in medicine, including disease diagnosis and drug detection.
Volume: 9 (15) Pages from: 4972 to: 4980
More Information: APC 2020. FT110100853. Advanced Cardiac Therapeutics, ACT. Australian Research Council, ARC. Australian National Fabrication Facility, ANFF. Australian National University, ANU, 2013 5659/002-001. – The authors acknowledge support from the Australian Research Council. This work was performed in part at the ACT node of the Australian National Fabrication Facility, a company established under the National Collaborative Research Infrastructure Strategy to provide nano and micro-fabrication facilities for Australian researchers. This research is supported by an Australian Government Research Training Program (RTP) Scholarship. N.B. Thanks Michael (Mun Hon) Cheah from Research School of Biology, ANU for providing critical equipment. N. B., K. E. C., I. S., I. A., Y. S. K. and D. N. N. acknowledge their participation in the Erasmus Mundus NANOPHI project, contract number 2013 5659/002-001. I. S. acknowledges the financial support by the Thuringian State Government within its ProExcellence initiative (APC 2020). D.-Y. C. is a recipient of the Australian Research Council Future Fellowship (Grant FT110100853). We thank A. Tittl and C. Ozdemir for useful discussions. N. B. and K. E. C. contributed equally to this workKeyWords: Nanostructures; Dielectric sensing; Proteins; Sensors; SURFACE-PLASMON RESONANCE
DOI: 10.1039/c6nr07904kCitations: 83data from “WEB OF SCIENCE” (of Thomson Reuters) are update at: 2022-05-22References taken from IsiWeb of Knowledge: (subscribers only)Connecting to view paper tab on IsiWeb: Click hereConnecting to view citations from IsiWeb: Click here