Improved cell activity on biodegradable photopolymer scaffolds using titanate nanotube coatings

Year: 2014

Authors: Beke S., Barenghi R., Farkas B., Romano I., Kőrösi L., Scaglione S., Brandi F.

Autors Affiliation: Nanophysics, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy; IEIIT, National Research Council (CNR), Via De Marini 6, 16149 Genova, Italy; Department of Biotechnology, Nanophage Therapy Center, Enviroinvest Corporation, Kertváros u. 2, H-7632 Pécs, Hungary; Istituto Nazionale di Ottica, CNR, Via G. Moruzzi 1, 56124-Pisa, Italy

Abstract: The development of bioactive materials is in the premise of tissue engineering. For several years, surface functionalization of scaffolds has been one of the most promising approaches to stimulate cellular activity and finally improve implant success. Herein, we describe the development of a bioactive composite scaffold composed of a biodegradable photopolymer scaffold and titanate nanotubes (TNTs). The biodegradable photopolymer scaffolds were fabricated by applying mask-projection excimer laser photocuring at 308 nm.TNTs were synthesized and then spin-coated on the porous scaffolds. Upon culturing fibroblast cells on scaffolds, we found that nanotubes coating affects cell viability and proliferation demonstrating that TNT coatings enhance cell growth on the scaffolds by further improving their surface topography. (C) 2014 Elsevier B.V. All rights reserved.


Volume: 44      Pages from: 38  to: 43

More Information: The authors are thankful for Alice Scarpellini and Paola Gavazzo for assisting in SEM imaging and cell culture experiments, respectively. This work has been supported in part by the European Community (FP7-NMP-2013-EU-China) grant agreement no. 604263 (NEUROSCAFFOLDS).
KeyWords: Laser photocuring; Scaffolds; Titanate nanotubes; Tissue engineering; Cell culturing
DOI: 10.1016/j.msec.2014.07.008

Citations: 17
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