Fiber optic nanoprobes for biological sensing
Authors: Barucci A., Berneschi S., Cosi F., Nunzi Conti G., Pelli S., Quercioli F., Soria S., Righini G.C.
Autors Affiliation: MDF Lab. Nello Carrara Institute of Applied Physics, IFAC-CNR, Sesto Fuiorentino (FI)Italy;
Centro Studi e Ricerche e Museo Storico della Fisica Enrico Fermi Roam Italy;
National Istitute of Optics, Sesto Fiorentino Branch, INO_CNR Italy
Abstract: Optical sensors have a large impact in the fields of life science research, drug discovery and medical diagnostics. The recent advances in nanotechnology and photonics have led to a new generation of nanotools, capable of probing even the single cell: it has already been demonstrated that nanobiosensors can detect biochemical targets and proteins inside living single cells. Here we provide a brief overview of the field of nanoprobes consisting of tapered, metal-coated optical fibers having nanosize tips, such as those which were originally developed for use in near-field optical microscopy. Moreover we present some preliminary results concerning the characterization of the experimental sensing system which exploits such nanoprobes for intracellular biomedical diagnostics. The feasibility of using the Fluorescence Lifetime Imaging Microscopy (FLIM) technique as a dynamic diagnostics tool with these nanoprobes has been demonstrated.
Journal/Review: PROCEEDINGS OF SPIE
Volume: 8011 Pages from: 80118X to: 80118X
KeyWords: Optical fibers; nanosensors; optical biosensors; fluorescence; FLIMDOI: 10.1117/12.902801Citations: 1data from “WEB OF SCIENCE” (of Thomson Reuters) are update at: 2019-09-15References taken from IsiWeb of Knowledge: (subscribers only)Connecting to view paper tab on IsiWeb: Click hereConnecting to view citations from IsiWeb: Click here